unpaired and paired two-sided t-test Search Results


r studio software  (RStudio)
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RStudio r studio software
R Studio Software, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chi-square test  (CH Instruments)
90
CH Instruments chi-square test
Chi Square Test, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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unpaired two-sided student’s t-test  (PolaRx Biopharmaceuticals Inc)
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PolaRx Biopharmaceuticals Inc unpaired two-sided student’s t-test
Unpaired Two Sided Student’s T Test, supplied by PolaRx Biopharmaceuticals Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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t test  (STATA Corporation)
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STATA Corporation t test
T Test, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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two-sided independent t-test  (CH Instruments)
90
CH Instruments two-sided independent t-test
Two Sided Independent T Test, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp loc103164333 cg04569152 g1  (Thermo Fisher)
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Thermo Fisher gene exp loc103164333 cg04569152 g1
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Gene Exp Loc103164333 Cg04569152 G1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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equivalence tests  (Minitab Inc)
86
Minitab Inc equivalence tests
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Equivalence Tests, supplied by Minitab Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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independent samples t-test  (MedCalc Software Ltd)
90
MedCalc Software Ltd independent samples t-test
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Independent Samples T Test, supplied by MedCalc Software Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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independent samples t-test - by Bioz Stars, 2026-11
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two-sided student’s t test  (RStudio)
90
RStudio two-sided student’s t test
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Two Sided Student’s T Test, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sigmaplot  (SYSTAT)
99
SYSTAT sigmaplot
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Sigmaplot, supplied by SYSTAT, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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two-sided t-test  (Rocha labs)
90
Rocha labs two-sided t-test
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Two Sided T Test, supplied by Rocha labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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student’s t-test  (CH Instruments)
90
CH Instruments student’s t-test
A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at <t>cg04569152.</t> Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.
Student’s T Test, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at cg04569152. Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.

Journal: Nature Communications

Article Title: Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy

doi: 10.1038/s41467-025-65845-2

Figure Lengend Snippet: A A total of 370 genes annotated to the heteroplasmy-associated CpGs were analyzed using DAVID, a comprehensive tool for functional annotation, disease association, and Gene Ontology (GO) analysis. Enrichment was assessed using DAVID’s modified Fisher’s exact test (EASE score), a two-sided test, detecting both over- and under-representation of terms relative to the background set. Enrichment analysis using the Genetic Association Database (GAD) revealed that these genes are enriched in metabolic traits and processes related to multicellular organization (a false discovery rate, FDR < 0.05). B GO biological pathway analysis of these 370 genes indicated enrichment in pathways related to signaling and neurodevelopment (FDR < 0.05). C Correlation between variant allele fraction (VAF) and CpG methylation at cg04569152. Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test). The mutation was introduced using the FusX TALE-based editing system (FusXTBE), and methylation was quantified by pyrosequencing. Linear correlation was assessed using Pearson’s method, supporting a potential epigenetic influence of mtDNA heteroplasmic variation on nuclear CpG methylation (see Supplementary Fig. ). D Integrative analysis of cg15233611( SETD1B ) illustrates its associations with mtDNA heteroplasmy burden, measured by the mitochondrial local constraint score sum (MSS), as well as with smoking, HDL cholesterol, and triglycerides, supported by methylation-trait associations and Mendelian randomization (MR). Pink circles with the positive sign (+) indicate a positive association, while blue circles with the negative sign (-) indicate a negative association. Association analyses were performed using linear regression, with significance assessed by two-sided t -tests for regression coefficients. Mendelian randomization (MR) analyses used the inverse-variance weighted (IVW) method, with significance assessed by two-sided Wald z-tests.

Article Snippet: Functional validation using HEK293T cell line editing and pyrosequencing demonstrated a significant positive correlation between VAF of an mtDNA nonsense mutation (mt.9979 in MT-COX3) and methylation levels at cg04569152 ( p = 0.003 from a two-sided t -test).

Techniques: Functional Assay, Modification, Variant Assay, CpG Methylation Assay, Biomarker Discovery, Mutagenesis, Methylation